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Tissue preservation in Onco-Fertility

Tissue preservation in Onco-Fertility

Cancer treatments such as chemotherapy and radiation can pose a significant threat to fertility, making it essential for patients to consider tissue preservation options before starting these therapies. Fertility preservation through advanced techniques offers cancer patients a chance to safeguard their reproductive potential and quality of life.

Tissue preservation in Onco-Fertility

Understanding Onco-Fertility

Onco-fertility is a medical field that combines oncology (cancer treatment) and reproductive medicine. It focuses on fertility preservation for cancer patients whose treatments might impair reproductive function. Common cancer therapies like chemotherapy and radiation can negatively affect ovarian and testicular function, posing challenges for future fertility.

The Need for Tissue Preservation

Cancer treatments, such as chemotherapy and radiation, can have detrimental effects on the ovaries and testes. For instance, chemotherapy can damage ovarian follicles in women, potentially leading to premature ovarian failure. Similarly, radiation therapy can harm the ovaries and testes, affecting sperm production and overall reproductive health. Tissue preservation offers an opportunity for cancer patients to retain their reproductive potential, either through ovarian or testicular tissue cryopreservation.

Services Offered

  • Ovarian Tissue Cryopreservation: In this procedure, a small piece of ovarian tissue is harvested and frozen for future use. After cancer treatment, the preserved tissue can be re-implanted, offering the potential to restore ovarian function.
  • Testicular Tissue Cryopreservation: This procedure involves the removal and freezing of testicular tissue, which may contain spermatogonial stem cells. Later, these cells can be transplanted to restore fertility.
  • Embryo and Oocyte Cryopreservation: This option involves freezing embryos or eggs before cancer treatment. These preserved reproductive cells can then be used for assisted reproductive techniques later.

Benefits of Tissue Preservation

  • Preserves future fertility: Cancer patients can safeguard their reproductive potential for the future.
  • Psychological assurance: Offers emotional peace and reassurance for patients facing cancer treatment.
  • Individualized care: Personalized assessment and treatment to meet the unique needs of each patient.

How Tissue preservation in Onco-Fertility is performed?

Initial Consultation:

  • A detailed discussion with a fertility specialist: This conversation aims to evaluate the patient’s overall health, including a thorough review of medical history, any previous fertility treatments, and the potential impact of cancer treatment on reproductive function.
  • Assessment of treatment plan: The fertility specialist will discuss the proposed cancer treatment regimen and its potential effects on fertility, allowing the team to customize the preservation plan accordingly.
  • Exploration of patient preferences: Understanding the patient’s priorities and goals will help guide the decision-making process and identify the most appropriate tissue preservation option.

Pre-Procedure Preparations:

  • Comprehensive evaluation of reproductive health: The specialist may conduct physical examinations, pelvic ultrasounds, or other imaging techniques to assess ovarian reserve in women and sperm count and motility in men.
  • Hormone level assessment: Blood tests, such as FSH (follicle-stimulating hormone), LH (luteinizing hormone), and AMH (anti-Müllerian hormone), may be performed to determine ovarian reserve and reproductive health.
  • Medical clearance: The patient’s overall health will be reviewed to ensure they are fit for the preservation procedure, considering the physical demands and emotional considerations.

Tissue Collection:

  • Minimally invasive procedure: For ovarian tissue preservation, a small portion of the ovarian cortex is surgically removed and collected. For testicular tissue preservation, a biopsy is performed to extract a small sample of testicular tissue.
  • Anaesthesia: Depending on the patient’s overall health and preferences, local or general anaesthesia may be administered to ensure a pain-free experience during the procedure.
  • Sample handling: The collected tissue is carefully prepared for cryopreservation in a controlled environment to maintain its integrity and viability.

Freezing and Storage:

  • Advanced cryopreservation techniques: The tissue samples are treated using sophisticated cryoprotectants and cooled to sub-zero temperatures. This process ensures the preservation of reproductive cells in a viable state for potential future use.
  • Storage: The preserved tissue is stored in specialized containers and kept in ultra-low-temperature storage facilities until needed for future use.

Post-Procedure Care:

  • Follow-up appointments: Regular consultations with the fertility specialist are scheduled to monitor hormone levels, reproductive health, and overall well-being.
  • Emotional support: Access to counseling and psychological support to help patients cope with the emotional and psychological aspects of undergoing cancer treatment and fertility preservation.
  • Recovery guidance: Clear instructions on aftercare, including potential side effects, recovery time, and any necessary lifestyle modifications.

By understanding each step of the tissue preservation in onco-fertility, patients can approach their treatment with confidence, knowing that they are in capable hands at Shukan Hospital & IVF Centre.

Risks of Tissue Preservation in Onco-Fertility

  • Infection: As with any surgical procedure, there is a risk of infection at the site of tissue collection.
  • Bleeding: There may be minor bleeding or bruising at the site of tissue collection.
  • Hormonal fluctuations: Following ovarian tissue collection, patients may experience temporary hormonal changes or fluctuations.
  • Reimplantation complications: When reimplanting ovarian or testicular tissue, there may be potential risks related to the procedure, including ovarian tissue viability and potential surgical complications.

At Shukan Hospital, we minimize these risks through meticulous planning, advanced technology, and comprehensive pre-operative and post-operative care.

Why Choose Shukan Hospital & IVF Centre in Ahmedabad for Tissue Preservation in Onco-Fertility?

  • We have inhouse team, experience embryologists and andrologists full time.
  • Highly experienced fertility specialists with specialized training in preserving fertility for cancer patients.
  • State-of-the-art cryopreservation methods and advanced laboratory facilities for optimal tissue preservation.
  • Expert guidance and emotional support throughout the process, from consultation to follow-up.
  • Detailed consultations and guidance on fertility preservation options, with a supportive environment for informed decisions.
  • Integrated care with oncology specialists to provide holistic treatment tailored to each patient’s needs.


How long does the tissue preservation process take?
The entire process, including initial consultation, pre-procedure preparations, tissue collection, and freezing can vary. Typically, the tissue collection procedure itself takes about 30 minutes to an hour.
Is the tissue collection procedure painful?
The procedure for tissue collection is minimally invasive and generally performed under local anesthesia. Some discomfort or cramping may be experienced, but it is typically well-tolerated.
What is the success rate of tissue preservation for onco-fertility?
Success rates vary depending on the individual case, the preservation technique, and the patient’s overall health. Success stories have shown positive outcomes, including ovarian function restoration and successful conception post-treatment.
How long can the preserved tissue be stored?
The preserved tissue can be stored indefinitely. Advances in cryopreservation techniques ensure the long-term viability of the preserved cells.
Are there any alternatives to tissue preservation?
Yes, alternatives like embryo or oocyte cryopreservation are also options before starting cancer treatment. These methods involve freezing embryos or eggs for future use.
How soon should tissue preservation be done after a cancer diagnosis?
It is ideal to perform tissue preservation before starting cancer treatment. This is because treatments like chemotherapy and radiation can quickly affect reproductive organs. Therefore, scheduling a consultation as soon as possible after diagnosis is recommended.
Can tissue preservation guarantee future fertility?
While tissue preservation can increase the chances of preserving fertility, there are no absolute guarantees. Success rates vary based on individual cases, the preservation technique, and the patient’s overall health. Advances in fertility treatments and reproductive technologies continue to improve outcomes.
Is tissue preservation safe for cancer patients?
Tissue preservation for onco-fertility is generally safe when performed by experienced medical professionals. The procedures are minimally invasive and are performed with a focus on patient safety and well-being.
Can tissue preservation affect my cancer treatment plan?
Tissue preservation procedures are minimally invasive and typically do not impact cancer treatment plans. However, it is essential to discuss this with your oncologist and fertility specialist to ensure there are no conflicts between treatments.
Can tissue preservation be performed alongside other cancer treatments?
Tissue preservation procedures can often be scheduled alongside other cancer treatments, but it is essential to coordinate between the oncologist and fertility specialist to ensure compatibility with the cancer treatment plan.
Are there any lifestyle changes I need to consider after tissue preservation?
Generally, no specific lifestyle changes are required after tissue preservation. Following the recommended post-procedure care guidelines is essential, and maintaining a healthy lifestyle can contribute to overall reproductive health.
How do I know if tissue preservation is right for me?
Scheduling a consultation with a fertility specialist is the best way to determine if tissue preservation is appropriate for you. During the consultation, your medical history, cancer treatment plan, and overall health will be evaluated to recommend the best approach.
Can I undergo tissue preservation more than once?
In some cases, patients may choose to undergo tissue preservation multiple times. It is essential to discuss the feasibility and potential risks with your healthcare provider.
Is tissue preservation for onco-fertility effective for all age groups?
Tissue preservation can be effective across various age groups, including adolescents, adults, and the elderly. The suitability and approach may vary based on individual health conditions and cancer treatments.
Can tissue preservation have an impact on cancer treatment timeline?
Tissue preservation procedures are typically scheduled alongside cancer treatment plans. Coordination between oncologists and fertility specialists ensures that the treatment timeline is not significantly impacted.
Can tissue preservation impact my hormone levels?
Tissue preservation procedures, particularly ovarian tissue collection, can impact hormone levels temporarily. However, this impact is usually minimal, and hormone levels typically return to baseline post-procedure.
Is tissue preservation suitable for pediatric cancer patients?
Yes, tissue preservation can be beneficial for pediatric cancer patients. However, the approach may require specific considerations and a tailored treatment plan based on the patient’s age and health.
What are the costs associated with tissue preservation for onco-fertility?
The cost of tissue preservation varies based on the type of procedure and the clinic. Insurance coverage may also vary, so it’s essential to discuss the financial aspects with your healthcare provider.